Suspected triclabendazole resistance in ewes with chronic fasciolosis

Veterinary RecordVolume 188, Issue 8 p. 300-303 SurveillanceFree Access Suspected triclabendazole resistance in ewes with chronic fasciolosis First published: 23 April 2021 https://doi.org/10.1002/vetr.426AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions of Use check box below share version article.I have read accept the Wiley Online Library UseShareable LinkUse link a this article your friends colleagues. Learn more.Copy URL Share linkShare onFacebookTwitterLinked InRedditWechat THE mean temperature Scotland February was 0.2°C long-term average, it coldest relative normal towards north east country. Rainfall 105 per cent average sunshine 116 average. Some southern/eastern areas were very wet, while far dry sunny. Cattle Generalised systemic conditions Two six-month-old pedigree Limousin calves from herd 30 noted neurological deficits. One more mildly affected ataxia short choppy gait. The other initially ataxic collapsed when moved or handled. It seemed improve briefly before deteriorating rapidly. A postmortem examination carried out on farm samples submitted for histopathology. This revealed an extensive, moderately severe, necrotising enteritis portal hepatitis, which indicative malignant catarrhal fever (MCF). PCR testing liver confirmed diagnosis. Examination brain non-suppurative angiocentric encephalitis cerebellar fibrinous meningitis consistent MCF. However, there also widespread cortical degeneration abiotrophy, most likely explanation signs second calf. ABOUT THIS REPORT monthly summary is produced Vet Record by Scotland's Rural College Services (SRUC VS) based reports its surveillance centres Edinburgh, Perth, St Boswells, Ayr (Auchincruive), Dumfries, Aberdeen, Inverness Thurso collaboration Moredun Research Institute University Glasgow School Medicine. SRUC VS are available online at www.sruc.ac.uk/downloads/120613/monthly_reports first every month. “Neonatal IBR usually seen naive animals introduced into infected late pregnancy DISEASE SURVEILLANCE HEADLINES, FEBRUARY Malignant abiotrophy calf Congenital erythropoietic porphyria Limousin-cross Illthrift deaths due sheep Basilar empyema tups protoporphyria diagnosed as cause rapid deterioration death one-month-old calf, sixth die 40 suckler cows. not known if related, history limited, but selected reported exhibit signs. Fixed tissues received, histopathology described deposition abundant brown pigment that exhibited bright red birefringence Maltese cross formation viewed under polarised light, mainly within hepatic and, lesser extent, alveolar septa. These findings considered typical congenital protoporphyria. Advice sampling further cases analysis, information genetic identify carriers, provided. condition thought autosomal recessive mode inheritance has been both cattle.1 Four group 53 either found dead died following period recumbency. Hereford stirk became recumbent unresponsive euthanased investigation problem. Postmortem extensive bilateral blackening epaxial lumbar midgluteal muscles. Fluorescent antibody proved positive Clostridium chauvoei organism isolated anaerobic culture, confirming diagnosis blackleg. Clostridial vaccination advised. one-week-old presented mucopurulent oculonasal discharge, increased upper respiratory noise, frothing mouth weakness. nasopharyngeal swab one bovine herpesvirus type 1 (BoHV-1) detected PCR. commented neonatal infectious rhinotracheitis (IBR) pregnancy. In case, born homebred dams, did vaccinate BoHV-1 status unknown. batch store cattle had onto six weeks previously shown month birth these calves. possible thus their receive protection circulating virus. Assessing passive transfer discussed. Musculoskeletal nine-month-old Highland heifer after month-long reducing motility, spells recumbency weight loss. Severe active purulent/necrotising arthritis identified clinical synovial membrane changes primary pyogenic infection limited lesions those associated Mycoplasma bovis. Cultures remained sterile; however, PCR/denaturing gradient gel electrophoresis fluid M Necrotising bronchiolitis bovis two cranioventral lung sections postulated may source secondary infection. Circulatory system disorders youngstock 35 three purchase. carcase second, 13-month-old Aberdeen Angus-cross, severe myocarditis pericarditis (Fig 1). Fig 1Open figure viewerPowerPoint Fibrinous association Histophilus somni cardiac form blackleg suspected no evidence C Histopathology suggested differential myocardial tissue tested PCR-positive high DNA load H somni. uncommon finding septicaemia. BLACK IN CATTLE Necrotic hepatitis novyi B (black disease) typically sudden sheep, often Fasciola hepatica asserted common than cattle; Scottish Investigation Diagnosis Analysis (VIDA) data 2016 2020 33 diagnoses only 16 sheep. frequently south west country, accounted 31 diagnoses. species, bacteria exist spores soil. ingested transported via circulation. They persist dormant state until local allow germination, multiplication production toxins. pathology black disease reviewed. 10 months 13 years age, aged between 64 Two-thirds made beef herds, remaining one-third dairy herds. Although death, 17 alive lethargic dull reduced appetite. More specific summarised A. AOpen Clinical some blood taken biochemistry glutathione dehydrogenase results up 100 times top end reference range. Only 27 F infection, indicating can proliferate absence parasitic damage. initiating factor evident. classical firm, pale lesion, bordered area haemorrhage B). Other findings, including subcutaneous oedema, pulmonary petechial haemorrhaging, chemosis pericardial effusion, related toxaemia. BOpen lesion fresh Carcases tend autolyse rapidly, provide diagnostic challenge as, obvious liver, becomes subtle autolyses. be fluorescent testing, cultures and/or Small ruminants Parasitic diseases Chronic illthrift flocks over 10-day February. All five carcases anaemic 2) large numbers bile ducts gall bladder. There submandibular oedema two. 2Open Anaemia all treatment autumn January/February 2021. Triclabendazole welfare reasons confirm appropriate time. ALERTS May 2020. Given similar climatic conditions, they could important year. Coccidiosis suckled incidence coccidiosis clearly peaks age making easier target prophylactic treatments required. number younger increases where prolonged cold spring weather poor grass growth delays turnout. Yolk sac gamebird chicks Chicks yolk infections days hatching peak mortality 4 6. Infection occur breeding farm, hatchery, during transport rearing site. range involved, Escherichia coli, Staphylococcus aureus Salmonella species. An note issued advising routine monitoring untested flocks, particularly used previous months. Undiagnosed fluke gestation lead problems metabolic disease, colostrum quality lamb viability. Alimentary tract farmer gimmers stocked kale access silage. on-farm petechiae abomasal mucosa. bacterial septicaemia detection mucosa muscularis raised possibility listerial abomasitis. Listeria monocytogenes lung, abomasitis Both silage soil sources case. Respiratory flock 60 mixed breeds lost Texel (all sired same tup) three-month period. Laryngeal chondritis second. third ewe recurrent death. Bilateral laryngeal abdominal originating diaphragm acute myofibre tearing connective vessels leading 3). damage repair scar identified. 3Open Degeneration sheep.2 Nervous basilar affecting separate holdings. On holding, 11-month-old tup anorexic day. abscess pituitary fossa 4) purulent exudate extended ventral meninges, ventricle lateral ventricles. 4Open case involved three-year-old blue treated antibiotics becoming failed respond 48 hours. seeding carotid rete mirabile animals. poll older tup. Skin Squamous cell carcinoma (SCC) six-year-old horn-like right side head. noticed earlier. densely cellular keratinising epithelial neoplasm SCC. Potential risk factors such include papillomavirus infections, ultraviolet radiation (particularly little skin pigmentation) trauma ear tagging punching. Birds Poultry Ovarian adenocarcinoma ex-battery hens loss condition. Multiple white, circular present ovaries birds. Similar mesentery intestinal serosa 5). 5Open Adenocarcinoma hen Wild birds female buzzard (Buteo buteo) good woodland adjacent garden fence establish Bruising swelling around eye extending slightly down neck 6). Clotted orbit globe intact, fractures grossly normal. Trauma, perhaps caused collision fence, cause. 6Open Liver analysis SASA (Science Agriculture) laboratory levels anticoagulant rodenticide residues (brodifacoum 0.307 mg/kg, bromadiolone 0.023 difethialone 0.002 mg/kg). excessive bleeding contributed bird. Miscellaneous species Deer five-year-old farmed deer hind being seven-day ataxia. appeared animal 220. unremarkable neuropathology symmetrical white matter brainstem myelopathy spinal cord hypocuprosis. copper low 80 μmol/kg (DM) (reference 180 300 DM) despite supplementation trace element bolus four previously, enzootic References 1McAloon CG, Doherty ML, O'Neill H, et al. Bovine crossbred Ireland. Ir J 2015; 68: 15, doi: 10.1186/s13620-015-0044-3CrossrefPubMedWeb Science®Google Scholar 2Waine K, Strugnell BW, Howie F, Diaphragmatic fatal Rec Case Rep 2018; 7:e000745 Google CONTACTING contacted telephone 0131 535 3130 email: [email protected] Contact details www.sruc.ac.uk/contactvetservices Volume188, Issue824 April/1 2021Pages FiguresReferencesRelatedInformation